Nuggets dark-mode light-mode

Tagged with Medical Research


Julia B. on the limitations of animal models

Julia B. writes on twitter:

There is no evidence that anything that extends lifespan in lower animals would have any lifespan extending effects in already long-lived humans. And conversely, no evidence that something with antiaging effects in humans would necessarily improve life/healthspan in rodents.

“One cannot assume that drug interventions in mice will automatically translate to humans, only about one in ten successful mouse cancer interventions ever makes it to the clinic & none of the 300+ mouse interventions in AD has proven effective in humans.” — You Have Come A Long Way Baby: Five Decades of Research on the Biology of Aging from the Perspective of a Researcher Studying Aging

Here’s a link to the NIA ITP (Interventions Testing Program), the only thing so far that seems to extend lifespan in both male/female mice (that won’t have side effects in humans) is seemingly Glycine. But then again I don’t think it really matters.

The benchmark must be de facto rejuvenation, like Mike/Irina Conboy et al has shown with Oxytocin + inhibition of systemic inflammation (systemic inflammation seems to lead to stem cell blockade). — Rejuvenation of brain, liver and muscle by simultaneous pharmacological modulation of two signaling determinants, that change in opposite directions with age